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New research has uncovered a possible reason women have a lower incidence of severe psoriasis than men.
According to the female hormone, estradiol plays a role in suppressing psoriasis and may have therapeutic potential.
By conducting experiments on mice, the researchers found that when the mice had their ovaries removed and were not supplemented with estradiol, they experienced severe skin inflammation.
However, when estradiol was administered, the production of certain cytokines responsible for inflammation was reversed, leading to a reduction in itching.
This effect was also observed in human immune cells in laboratory tests.
The researchers discovered that estradiol regulates the activity of immune cells involved in psoriatic inflammation.
These findings contribute to a better understanding of the role of estradiol and may have implications for future treatments for psoriasis.
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